desvenlafaxine will raise the level or result of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Watch. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, four hundred mg) decrease the CYP2D6 substrate dose by nearly 50%; no dosage adjustment wanted with desvenlafaxine doses seven consecutive times instantly prior to getting alvimopan).
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No substantial conversation is expected with concurrent usage of opioid analgesics and alvimopan in patients who been given opioid analgesics for 7 or less consecutive times ahead of alvimopan.